The Gamma Globulins and Their Clinical Significance

IN 1948 Arne Tiselius was awarded the Nobel Prize for having developed the technic of electrophoresis, which separates the serum proteins into four major fractions: albumin, and three distinct globulins named alpha, beta and gamma. Since Tiselius1 first identified the gamma globulins as the major antibody proteins, progress in elucidating their physiologic and clinical significance has advanced steadily. Measurement of changes in the amount of serum gamma globulins has proved useful in the diagnosis of disease, and the development of practical plasma-fractionation technics by E. J. Cohn and his co-workers in the early nineteen forties has provided human gamma globulins . . .