Population
Mouse embryonal teratocarcinoma F9 cells differentiated into yolk-sac endoderm-like cells, and mouse embryos
Comparison
Cubilin antibodies, RAP, and various… vs Control IgG, ovalbumin, or untreated cells
Design
Preclinical, double-blinded fashion for evaluating yolk-sac fluorescence
Authors
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May implicate cubilin in embryonic HDL handling; leaves open translational relevance to human cardiovascular risk.
Cubilin was identified as a specific endocytic receptor for HDL holoparticles, mediating its uptake and lysosomal degradation in yolk-sac endoderm.
Hammad et al. (1999) studied this question.
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