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March 1, 1989Clinical Orthopaedics and Related Research

Bone Transplantation and Human Immunodeficiency Virus

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Authors

BBB.E. BuckCenters for Disease Control and PreventionTMTheodore I. MalininUniversity of MiamiMBMark D. BrownIndiana University School of Medicine

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Implication

Risk analysis reveals minimal HIV transmission risk in bone allografts, indicating the necessity of rigorous multi-step donor screening.

Key Points

  • To estimate the risk of transmitting human immunodeficiency virus through bone allografts under different donor screening and testing protocols.
  • Calculated transmission probabilities using mathematical risk modeling based on average population estimates.
  • Evaluated a comprehensive screening protocol comprising donor history exclusion, testing for HIV antigens and antibodies, and donor tissue histopathologic evaluation.
  • Modeled alternative risk scenarios evaluating inadequate donor testing regimens, such as antibody screening alone.
  • The probability of acquiring a bone allograft from an undetected HIV-infected donor is calculated at less than one in one million when combining rigorous donor selection, antigen and antibody screening, and tissue histopathology.
  • The estimated transmission risk increases to as high as one in 161 when donor evaluation relies solely on HIV antibody testing without comprehensive precautions.

Cite This Study

Buck et al. (1989) studied this question.

synapsesocial.com/papers/6a6faccfc92390ac2d07a635https://doi.org/10.1097/00003086-198903000-00015
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1STERILIZATION OF HIV WITH IRRADIATION: RELEVANCE TO INFECTED BONE ALLOGRAFTS1999 · 88 citations
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  4. 4Survival of kidney transplantation in people living with HIV/AIDS: a systematic review and meta-analysis2025 · 2 citations
  5. 5AUTOLOGOUS PERIPHERAL BLOOD STEM CELL TRANSPLANTATION IN PATIENTS WITH HIV-ASSOCIATED LYMPHOPROLYPHERATIVE DISORDER2024