Relationship between aspirin/clopidogrel resistance and intra-stent thrombi assessed by follow-up optical coherence tomography after drug-eluting stent implantation
Why the study?
Does aspirin/clopidogrel resistance predict intra-stent thrombi on follow-up OCT in DES-treated patients?
Population
308 DES-treated patients who underwent follow-up OCT and simultaneous measurement of aspirin reaction unit…
Comparison
Aspirin and/or clopidogrel resistance vs Absence of aspirin and/or clopidogrel resistance
Design
Cohort
Follow-up
mean 195 ± 133 days
Authors
Discussion
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Member takes
Implication
Antiplatelet resistance testing does not predict intra-stent thrombi on OCT after DES; leaves open stent length as a procedural factor for further study.
Structured PICO
Does aspirin/clopidogrel resistance predict intra-stent thrombi on follow-up OCT in DES-treated patients?
P
Population
308 DES-treated patients who underwent follow-up OCT and simultaneous measurement of aspirin reaction unit (ARU) and P2Y12 reaction unit (PRU) using the VerifyNow assay system
I
Intervention
Aspirin and/or clopidogrel resistance (defined as ARU ≥550 and PRU ≥275, respectively)
C
Comparator
Absence of aspirin and/or clopidogrel resistance
O
Outcome
Presence of intra-stent thrombi on follow-up OCTsurrogate
Intra-stent thrombi detected on follow-up OCT after DES implantation are associated with longer stent length rather than aspirin or clopidogrel resistance.
Cite This Study
Park et al. (2013) studied this question.