Demonstrates extensive homologous recombination among TT viruses, particularly in noncoding regions.
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Recombination hotspots may necessitate revised TT virus detection strategies; leaves open effects on persistence and clinical associations.
Analyses of a collection of full-length TT virus genomes showed nearly half of them to be recombinant. The results were highly significant and revealed homologous recombination both within and among genotypes, often involving extremely divergent lineages. Recombination breakpoints were significantly more common in the noncoding region of the TT virus genome than in the coding region.
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Michael Worobey (2000) studied this question.
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