TT virus circulates as quasispecies with amino acid substitutions in hypervariable regions, likely to evade host immune surveillance.
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May inform TT virus immune evasion strategies; leaves open clinical relevance pending validation in human cohorts.
Three hypervariable regions were identified in a central portion of open reading frame 1 of TT virus DNA, which codes for a putative capsid protein of 770 amino acids. TT virus circulates as quasispecies, with many amino acid substitutions in hypervariable regions, to evade immune surveillance of the hosts and to establish a persistent infection.
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Nishizawa et al. (1999) studied this question.
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