What question did this study set out to answer?

This research aims to identify and compare two distinct types of astrocytes within developing rat white matter, focusing on their morphology and growth traits.

June 1, 1983Journal of NeuroscienceOpen Access

Two types of astrocytes in cultures of developing rat white matter: differences in morphology, surface gangliosides, and growth characteristics

View Full Paper

Ask AI

Bookmark

Authors

MRM C RaffUniversity College Hospital EAER AbneyUCL Australia JCJeffrey A. CohenDartmouth Health

Discussion

Member takes

Implication

Randomized trial reveals differences in astrocyte types in developing rat optic nerve, indicating distinct growth characteristics.

Key Points

This research aims to identify and compare two distinct types of astrocytes within developing rat white matter, focusing on their morphology and growth traits.
Cultures of developing rat optic nerve were established to identify GFAP+ astrocytes.
Morphological characteristics and binding affinity to specific ligands (tetanus toxin, A2B5) of astrocytes were analyzed.
Growth responses to bovine pituitary extract and epidermal growth factor (EGF) were tested.
Type 1 astrocytes displayed a fibroblast-like morphology and were stimulated to divide by EGF, whereas Type 2 astrocytes had a neuron-like morphology and did not respond to EGF.
Only Type 1 astrocytes were present in gray matter cultures, while both types existed in white matter cultures.
Type 2 astrocytes developed from GFAP- cells in neonatal optic nerves, and ligands bound by these astrocytes are not neuron-specific.

Cite This Study

Raff et al. (1983) studied this question.

synapsesocial.com/papers/6a6fae4bc92390ac2d07a682 https://doi.org/10.1523/jneurosci.03-06-01289.1983

View Full Paper

Ask AI

Bookmark

Two types of astrocytes in cultures of developing rat white matter: differences in morphology, surface gangliosides, and growth characteristics

Discussion

Member takes

Implication

Key Points

Cite This Study

Two types of astrocytes in cultures of developing rat white matter: differences in morphology, surface gangliosides, and growth characteristics

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider