Realization of the first sub-shot-noise wide field microscope

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Recently, several proof of principle experiments have demonstrated the advantages of quantum technologies over classical schemes. The present challenge is to surpass the limits of proof of principle demonstrations to approach real applications. This letter presents such an achievement in the field of quantum enhanced imaging. In particular, we describe the realization of a sub-shot-noise wide field microscope based on spatially multi-mode non-classical photon number correlations in twin beams. The microscope produces realtime images of 8000 pixels at full resolution, for a 500 μm2 field of view, with noise reduced to 80% of the shot noise level (for each pixel), which is suitable for absorption imaging of complex structures. By fast post-elaboration, specifically applying a quantum enhanced median filter, the noise can be further reduced (to <30% of the shot noise level) by setting a trade-off with the resolution, thus achieving the best sensitivity per incident photon reported in absorption microscopy. A new microscope instantly captures thousands of photons from faint objects with signal-to-noise ratios exceeding classical limits. Imaging of sensitive objects, such as live cells, limits the optical power that lasers can apply. Now, Alice Meda from Italy's INRIM and colleagues have developed a microscope that ’squeezes‘ light to overcome intensity-limiting shot noise caused by quantum fluctuations of photons. Their sub-shot-noise microscope uses a nonlinear crystal to generate two high correlated light beams impossible for classical waves. Microscale pixels recorded intensities when one beam strikes a sample can have their shot noise reduced by 20% by subtracting correlated patterns from the second reference beam. This quantum-enhanced noise reduction enables the microscope to operate for high sensitive, dynamic, wide field, Q imaging applications.