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May 26, 2004Journal of VirologyOpen Access

Inter- and Intragenus Structural Variations in Caliciviruses and Their Functional Implications

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Population

Recombinant capsids of Grimsby virus, Parkville virus, San Miguel sea lion virus serotype 4, and Norwalk virus

Design

Preclinical

Authors

RCRong ChenHebei Medical UniversityJNJohn D. NeillAgricultural Research ServiceJNJacqueline S. NoelThe Pelvic Floor Institute

Discussion

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Implication

Animal calicivirus capsid variations warrant no clinical translation yet; leaves open P2 subdomain roles in human strain specificity.

Structured PICO

P
Population
Recombinant capsids of Grimsby virus, Parkville virus, San Miguel sea lion virus serotype 4 (SMSV4), and Norwalk virus
I
Intervention
Structural studies and comparative analysis
O
Outcome
Inter- and intragenus structural variations

Comparative structural studies of caliciviruses reveal a modular domain organization where the hypervariable P2 subdomain may confer host specificity and strain diversity.

Cite This Study

Chen et al. (2004) studied this question.

synapsesocial.com/papers/6a6faf2a5d37378ac1dcbdc0https://doi.org/10.1128/jvi.78.12.6469-6479.2004
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Improved methods for building protein models in electron density maps and the location of errors in these models1991 · 12,688 citations
  2. 2Isolation of Enzymatically Active Replication Complexes from Feline Calicivirus-Infected Cells2002 · 72 citations
  3. 3Characterization of Two New Serotypes of San Miguel Sea Lion Virus1977 · 31 citations
  4. 4Molecular Epidemiology of “Norwalk‐like Viruses” in Outbreaks of Gastroenteritis in the United States1998 · 462 citations
  5. 5ANTIBODY-ANTIGEN COMPLEXES1990 · 852 citations