What question did this study set out to answer?

To evaluate serum and faecal antibody responses in patients with haemorrhagic colitis caused by verocytotoxin-producing Escherichia coli O157 compared to matched controls.

December 1, 1993Journal of Medical Microbiology

Detection of serum and faecal antibodies in haemorrhagic colitis caused by Escherichia coli O157

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To evaluate serum and faecal antibody responses in patients with haemorrhagic colitis caused by verocytotoxin-producing Escherichia coli O157 compared to matched controls.
Serum samples from 28 culture-confirmed cases and 34 age- and sex-matched controls were tested for VT1- and VT2-neutralising antibodies, agglutinating antibodies, and IgG against lipopolysaccharide and whole cells.
Faecal samples from 93 cases and 47 matched controls were assessed for specific IgA antibodies using a whole-cell enzyme immunoassay (EIA).
Cases had significantly higher serum antibody titres than controls for agglutinating antibodies (p < 0.05) and whole-cell IgG antibodies (p < 0.001) by Wilcoxon two-sample testing.
Elevated faecal IgA specific for E. coli O157 was present in 59 of 93 cases (63.4%) compared to 10 of 47 controls (21.2%; p < 0.001).
Serial faecal testing in five cases demonstrated marked rises in IgA that coincided with the cessation of bacterial shedding.

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Implication

Case-control study demonstrates elevated serum IgG and faecal IgA antibodies in haemorrhagic colitis patients, highlighting their utility for diagnosing Escherichia coli O157 infections.

Cite This Study

Siddons et al. (1993) studied this question.

synapsesocial.com/papers/6a6faf2b75498292b709109d https://doi.org/10.1099/00222615-39-6-408

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Implication

Case-control study demonstrates elevated serum IgG and faecal IgA antibodies in haemorrhagic colitis patients, highlighting their utility for diagnosing Escherichia coli O157 infections.

Detection of serum and faecal antibodies in haemorrhagic colitis caused by Escherichia coli O157

Key Points

Discussion

Implication

Cite This Study

Detection of serum and faecal antibodies in haemorrhagic colitis caused by Escherichia coli O157

Key Points

Discussion

Implication

Cite This Study