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August 24, 2012Journal of Applied Physiology

EndEx enhanced ACh sensitivity in G2A-R and G2A-W arterioles (+36.0% and +31.7%), while IST increased sensitivity only in G2A-R (+35.5%); both improved HbA1c (5.39% and 5.30% vs 6.84% in sedentary).

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Why the study?

Does endurance exercise or interval sprint training improve skeletal muscle microvascular endothelial function in a rat model of type 2 diabetes?

Population

20-wk-old Otsuka Long Evans Tokushima fatty (OLETF) rats with advanced insulin resistance

Comparison

12 weeks of endurance exercise or interval… vs Sedentary OLETF rats

Design

Preclinical

Follow-up

12 weeks

Authors

JMJeffrey S. MartinJPJaume PadillaNJNathan T. Jenkins

Discussion

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Overview

Should not alter exercise prescriptions; leaves open optimal regimens for human microvascular endothelial function in T2D.

Structured PICO

Does endurance exercise or interval sprint training improve skeletal muscle microvascular endothelial function in a rat model of type 2 diabetes?

P
Population
20-wk-old Otsuka Long Evans Tokushima fatty (OLETF) rats with advanced insulin resistance
I
Intervention
12 weeks of endurance exercise (EndEx) or interval sprint training (IST)
C
Comparator
Sedentary OLETF rats
O
Outcome
Endothelial-dependent dilation to acetylcholine (ACh) and vasoreactivity to insulin in isolated, pressurized skeletal muscle resistance arteriolessurrogate

Different exercise paradigms produce spatially differential adaptive responses in skeletal muscle microvascular endothelial function in a rat model of type 2 diabetes.

Cite This Study

Martin et al. (2012) studied this question.

synapsesocial.com/papers/6a6faf346c240de38cdb8defhttps://doi.org/10.1152/japplphysiol.00823.2012
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