December 16, 2004AJP Regulatory Integrative and Comparative Physiology

Exercise-induced increase in skeletal muscle vasodilatory responses in obese Zucker rats

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Why the study?

Does treadmill exercise training improve microvascular function in obese Zucker rats?

Structured PICO

Does treadmill exercise training improve microvascular function in obese Zucker rats?

Population

Obese Zucker rats (a model of obesity and type II diabetes) and lean controls, divided into four age-matched groups: lean sedentary (LS), lean exercise (LE), obese sedentary (OS), and obese exercise (OE).

Intervention

Treadmill exercise training from 5 to 11 weeks of age, including a 2-week acclimation period.

Comparator

Sedentary controls (lean sedentary and obese sedentary groups).

Outcome

Microvascular function, specifically functional hyperemia and endothelial-dependent vasodilation (acetylcholine-induced) in the spinotrapezius muscle measured using intravital microscopy.surrogate

Exercise training improves microvascular function and metabolic markers in a rat model of obesity and type II diabetes, independent of blood pressure changes.

Discussion

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Implication

Supports microvascular benefits of exercise in obese diabetic models; leaves open translation to human therapy pending clinical trials.

Cite This Study

Xiang et al. (2004) studied this question.

synapsesocial.com/papers/6a8350d3e70fdf012930e57d https://doi.org/10.1152/ajpregu.00702.2004

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Exercise-induced increase in skeletal muscle vasodilatory responses in obese Zucker rats

Structured PICO

Discussion

Implication

Cite This Study

Exercise-induced increase in skeletal muscle vasodilatory responses in obese Zucker rats

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider