Why the study?
Does a single 75 mg intramuscular dose of warfarin produce effective hypoprothrombinemia and is it well tolerated in patients?
Does a single 75 mg intramuscular dose of warfarin produce effective hypoprothrombinemia and is it well tolerated in patients?
Intramuscular administration of a single 75 mg dose of warfarin is feasible, well-tolerated, and provides therapeutic anticoagulation for up to five days, allowing for home administration.
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Single-dose IM warfarin may enable short-term outpatient anticoagulation; this case report leaves open generalizability and safety in larger cohorts.
Shepard Shapiro (1957) studied this question.
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