Key result
Warfarin sodium administered every three or four days was evaluated for maintaining therapeutic prothrombin concentrations, though quantitative results are not reported in the truncated abstract.
Why the study?
Does warfarin sodium administered every three or four days maintain prothrombin concentration in an acceptable therapeutic range in patients requiring prolonged anticoagulant therapy?
Observational
Does warfarin sodium administered every three or four days maintain prothrombin concentration in an acceptable therapeutic range in patients requiring prolonged anticoagulant therapy?
The study explores whether less frequent, larger doses of warfarin can safely maintain therapeutic anticoagulation while reducing the need for daily monitoring.
Intermittent warfarin dosing lacks quantitative support for therapeutic maintenance; leaves open whether reduced-frequency regimens can safely minimize monitoring in prolonged anticoagulation.
Recent reports * have indicated that therapeutic hypoprothrombinemia may be produced and maintained safely and effectively by the administration of the 4-hydroxycoumarin compound, warfarin sodium.† The rapidity of onset and duration of action of warfarin sodium has suggested that perhaps in instances where prolonged anticoagulant therapy is anticipated warfarin sodium could be administered with less frequency in somewhat larger doses, obviating the necessity for a daily prothrombin determination. This would appear to be a distinct advantage if, after a period of careful observation, a dose could be administered every three or four days that might be predicted with a reasonable degree of accuracy to maintain the prothrombin concentration in an acceptable therapeutic range. Concomitant with good predictability a lessening of the frequency for prothrombin determinations would be realized, with resultant economy. Our clinical studies were directed by this premise, and presentation of these observations is given, together with a comparison of
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Dallas V. Clatanoff (1956) conducted an observational in Anticoagulant therapy. Warfarin sodium was evaluated on Prothrombin concentration in an acceptable therapeutic range. Warfarin sodium administered every three or four days was evaluated for maintaining therapeutic prothrombin concentrations, though quantitative results are not reported in the truncated abstract.