Why the study?
Does the initial prothrombin ratio on the third day of warfarin therapy predict the required maintenance dose in hospital patients?
Does the initial prothrombin ratio on the third day of warfarin therapy predict the required maintenance dose in hospital patients?
The prothrombin ratio on the third day of initial 10 mg daily warfarin therapy significantly correlates with the final maintenance dose, suggesting a method for early dose prediction.
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May aid early warfarin dose prediction in hospital patients; hypothesis-generating and requires prospective validation before practice change.
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Miller et al. (1979) studied this question.
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