Key result
A flexible dose induction protocol for warfarin initiation matched empirical prescribing for reaching therapeutic INR, and predicted maintenance dose to within 1 mg in 69% of patients (95% CI 59-79%).
Why the study?
Does a flexible dose induction protocol improve INR control and prevent excessive warfarin effect compared to empirical prescribing in inpatients requiring warfarin?
Population
172 inpatients in two general hospitals requiring initiation of warfarin therapy
Comparison
Warfarin dosage determined using a flexible dose… vs Warfarin dosage prescribed empirically by…
Design
RCT, randomly assigned
Authors
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Supports standardized warfarin initiation in inpatients; confirms equivalence to empirical dosing with reliable maintenance dose prediction.
RCT (n=172)
Randomly assigned
Yes
Does a flexible dose induction protocol improve INR control and prevent excessive warfarin effect compared to empirical prescribing in inpatients requiring warfarin?
A standardized flexible dose induction protocol for warfarin is as effective as empirical prescribing by medical staff and may reduce the risk of excessive anticoagulation.
Doecke et al. (1991) conducted an RCT in Inpatients requiring warfarin therapy (n=172). Flexible dose induction protocol for warfarin vs. Empirical dosage prescribed by resident medical staff was evaluated on Mean INR, time to reach therapeutic INR, and maintenance dose. A flexible dose induction protocol for warfarin initiation matched empirical prescribing for reaching therapeutic INR, and predicted maintenance dose to within 1 mg in 69% of patients (95% CI 59-79%).
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