Why the study?
Does a warfarin initiation regimen of 2 mg daily for 2 weeks with maintenance dose predicted by week-2 INR and sex achieve target INR in out-patients?
Population
213 consecutive out-patients requiring oral anticoagulation, mean age 70-71 years.
Design
Cohort
Follow-up
6-8 weeks
Authors
Loading...
May support outpatient 2 mg warfarin initiation with INR-guided dosing; hypothesis-generating for algorithms, needing RCTs before practice change.
Does a warfarin initiation regimen of 2 mg daily for 2 weeks with maintenance dose predicted by week-2 INR and sex achieve target INR in out-patients?
An out-patient warfarin initiation regimen using 2 mg daily for 2 weeks followed by a maintenance dose predicted by week-2 INR and patient sex safely achieves target INR in the majority of patients.
Oates et al. (1998) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: