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June 1, 1998British Journal of HaematologyOpen Access

A warfarin induction regimen for out‐patient anticoagulation in patients with atrial fibrillation

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Why the study?

Does a 5 mg initial dose warfarin induction regimen reduce supratherapeutic INRs compared to a 10 mg regimen in patients with atrial fibrillation?

Population

74 patients with atrial fibrillation requiring anticoagulation. 5 patients on amiodarone were excluded from…

Comparison

Warfarin induction regimen employing an initial… vs Traditional warfarin protocol employing an…

Design

Cohort, non-randomized

Follow-up

21 days

Authors

RTRobert C. TaitUniversity of VermontSSefcickSouthern General Hospital

Discussion

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Implication

May reduce supratherapeutic INRs with 5 mg vs 10 mg warfarin start in AF; hypothesis-generating and needs randomized confirmation.

Structured PICO

Does a 5 mg initial dose warfarin induction regimen reduce supratherapeutic INRs compared to a 10 mg regimen in patients with atrial fibrillation?

P
Population
74 patients with atrial fibrillation requiring anticoagulation (37 out-patients, 37 in-patients). 5 patients on amiodarone were excluded from the final analysis.
I
Intervention
Warfarin induction regimen employing an initial 5 mg dose (out-patient setting)
C
Comparator
Traditional warfarin protocol employing an initial 10 mg dose (in-patient setting)
O
Outcome
Maximum International Normalized Ratio (INR) during the first 21 days of therapysurrogate

A 5 mg initial dose for warfarin induction is safer and more reliable than a traditional 10 mg dose for out-patients with atrial fibrillation, resulting in fewer supratherapeutic INRs.

Cite This Study

Tait et al. (1998) studied this question.

synapsesocial.com/papers/6a72549984cc45bb7be01a37https://doi.org/10.1046/j.1365-2141.1998.00716.x

Topics

Atrial fibrillationAnticoagulation in AFPersistent AF management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Flexible induction dose regimen for warfarin and prediction of maintenance dose.1984 · 165 citations
  2. 2Factors affecting the maintenance dose of warfarin.1992 · 177 citations
  3. 3Risk Factors for Complications of Chronic Anticoagulation: A Multicenter Study1993 · 674 citations
  4. 4Methods for managing the increased workload in anticoagulant clinics: Table 11996 · 22 citations
  5. 5Effect of age upon the induction and maintenance of anticoagulation with warfarin1995 · 36 citations