Detection of human calicivirus antigen and antibody by enzyme-linked immunosorbent assays
Population
163 stool samples from children hospitalized with diarrhea, and serum samples from hospitalized infants and…
Comparison
Enzyme-linked immunosorbent assays for human… vs Radioimmunoassay (for sensitivity comparison)
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Supports ELISA for calicivirus detection in children; leaves open its diagnostic role in diarrhea management.
Structured PICO
P
Population
163 stool samples from children hospitalized with diarrhea, and serum samples from hospitalized infants and children (birth to 19 years) without gastroenteritis and healthy adults in the United States.
I
Intervention
Enzyme-linked immunosorbent assays (ELISAs) for human calicivirus (HCV) antigen and antibody
C
Comparator
Radioimmunoassay (for sensitivity comparison)
O
Outcome
Detection of human calicivirus (HCV) antigen and antibodysurrogate
ELISAs can effectively detect human calicivirus, revealing that HCV infections are common and acquired early in childhood in the United States.
Cite This Study
Nakata et al. (1988) studied this question.