Myofibril breakdown during atrophy is a delayed response requiring the transcription factor PAX4 and desmin depolymerization
Population
Mice (mouse tibialis anterior muscles)
Design
Preclinical
Follow-up
14 days
Authors
Discussion
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Member takes
Implication
Denervation atrophy spares early myofibril loss unlike fasting; leaves open distinct Trim32-targeted interventions for disuse vs cachexia.
Structured PICO
P
Population
Mice (mouse tibialis anterior muscles)
I
Intervention
Denervation (disuse) or fasting; down-regulation of Trim32 or PAX4
O
Outcome
Myofibril breakdown and desmin depolymerizationsurrogate
Myofibril breakdown during muscle atrophy requires an initial Trim32-dependent disassembly of desmin filaments followed by PAX4-mediated gene induction.
Cite This Study
Volodin et al. (2017) studied this question.