Why the study?
Does UCP3 ablation exacerbate high-salt induced cardiac hypertrophy and dysfunction in mice?
Does UCP3 ablation exacerbate high-salt induced cardiac hypertrophy and dysfunction in mice?
UCP3 ablation exacerbates high-salt-induced cardiac hypertrophy, dysfunction, and mitochondrial respiratory dysfunction in mice, suggesting a protective role for UCP3 in early heart failure.
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UCP3 ablation worsens salt-induced cardiac remodeling in mice; leaves open any role in human hypertension or HF.
Lang et al. (2018) studied this question.
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