Enteric Viruses and Diarrhea in HIV-Infected Patients
Why the study?
Are novel enteric viruses associated with diarrhea in HIV-infected patients?
Population
HIV-infected patients enrolled in a longitudinal study in Atlanta, providing 109 fecal specimens from…
Comparison
Screening of fecal specimens by electron… vs Control patients without diarrhea.
Design
Cohort
Authors
Discussion
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Member takes
Implication
Supports viral testing in HIV diarrhea evaluation; leaves open causality and need for prospective trials.
Structured PICO
Are novel enteric viruses associated with diarrhea in HIV-infected patients?
P
Population
HIV-infected patients enrolled in a longitudinal study in Atlanta, providing 109 fecal specimens from patients with diarrhea and 113 specimens from control patients without diarrhea.
I
Intervention
Screening of fecal specimens by electron microscopy, polyacrylamide-gel electrophoresis, and enzyme immunoassays for enteric viruses.
C
Comparator
Control patients without diarrhea.
O
Outcome
Detection of enteric viruses (rotaviruses, enteric adenoviruses, caliciviruses, picobirnaviruses, and astroviruses).
Novel enteric viruses such as astrovirus and picobirnavirus are significantly associated with diarrhea in HIV-infected patients.
Cite This Study
Grohmann et al. (1993) studied this question.