The murine homolog of human LIMS1 maps to proximal Chromosome 10, identifying it as a candidate gene for the waltzer deafness mutation.
Answers are grounded in this paper and cite their sources.
Supports Lims1l candidacy for murine waltzer deafness; leaves open human disease relevance pending validation.
The human LIM domain gene LIMS1 was used to identify a mouse homolog. The resulting mouse sequence was used to identify a polymorphism by SSCP analysis. Linkage studies performed in the EUCIB backcross placed Lims1l on the proximal portion of mouse Chromosome 10. This localisation makes it an interesting candidate for the deafness mutant, waltzer (v).
No takes yet. Share an insight, caveat, or question.
Abu‐Hayyeh et al. (1998) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: