Why the study?
Does monotherapy or combination therapy with digoxin, beta-blockers, or calcium antagonists improve heart rate control, symptoms, and exercise tolerance in patients with chronic atrial fibrillation?
Does monotherapy or combination therapy with digoxin, beta-blockers, or calcium antagonists improve heart rate control, symptoms, and exercise tolerance in patients with chronic atrial fibrillation?
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Beta-blocker or calcium antagonist monotherapy should not be first-line for chronic AF symptoms; challenges guidelines and supports digoxin-based regimens.
Nikolaidou et al. (2009) studied this question.
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