September 1, 1986Proceedings of the National Academy of SciencesOpen Access

Conservation of amino acid sequence of VP8 and cleavage region of 84-kDa outer capsid protein among rotaviruses recovered from asymptomatic neonatal infection.

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Population

Four pairs of asymptomatic and virulent human rotaviruses and a simian rotavirus propagated in African…

Comparison

Dideoxynucleotide sequencing of the region of… vs Comparison between asymptomatic and virulent…

Design

Preclinical

Authors

MGM GorzigliaUniversidad de Los Andes, Chile YHYasutaka HoshinoNational Institute of Infectious Diseases ABAlicia Buckler‐WhiteNational Institute of Allergy and Infectious Diseases

Discussion

Member takes

Implication

Hypothesis-generating for rotavirus virulence markers; leaves open applicability to human disease prediction or management.

Structured PICO

Population

Four pairs of asymptomatic and virulent human rotaviruses (Wa, M37, DS-1, 1076, P, McN, VA70, ST3) and a simian rotavirus (RRV MMU18006) propagated in African monkey kidney cells (MA104).

Intervention

Dideoxynucleotide sequencing of the region of the fourth gene coding for the VP8 protein, downstream cleavage sites, and the NH2 terminus of VP5.

Comparator

Comparison between asymptomatic and virulent human rotavirus strains, and simian rotavirus.

Outcome

Amino acid sequence homology and conservation at specific positions.surrogate

Sequence dimorphism in the VP8 protein and cleavage region of the fourth gene may be responsible for the difference in virulence between asymptomatic and virulent human rotaviruses.

Cite This Study

Gorziglia et al. (1986) studied this question.

synapsesocial.com/papers/6a6fb3118031ec7bb1dbe5aa https://doi.org/10.1073/pnas.83.18.7039

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Conservation of amino acid sequence of VP8 and cleavage region of 84-kDa outer capsid protein among rotaviruses recovered from asymptomatic neonatal infection.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Conservation of amino acid sequence of VP8 and cleavage region of 84-kDa outer capsid protein among rotaviruses recovered from asymptomatic neonatal infection.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider