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This research investigates the serotype classification and cross-protection properties of various animal rotaviruses.

Antigenic relationships among some animal rotaviruses: virus neutralization in vitro and cross-protection in piglets

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Randomized trial compares virus neutralization and cross-protection among animal rotaviruses in piglets, indicating vaccine serotype importance.

This research investigates the serotype classification and cross-protection properties of various animal rotaviruses.
Viruses from canine, simian, porcine, and human species were compared in vitro using serum neutralization tests.
Cell culture adaptation and cloning were performed for specific strains to assess their protective abilities against rotavirus challenge in gnotobiotic piglets.
Cross-protection studies were conducted to test vaccine efficacy against the virulent porcine Ohio State University strain.
Four major serotype groups were identified: bovine, human, porcine, and canine-simian strains.
Only the porcine strain provided protection against the virulent challenge; other vaccines failed to protect gnotobiotic piglets.
The canine virus showed cross-protection against the simian strain, confirming differences in RNA segments.

Gaul et al. (1982) studied this question.

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Randomized trial compares virus neutralization and cross-protection among animal rotaviruses in piglets, indicating vaccine serotype importance.