Amino acid substitutions in the VP7 antigenic regions of Chinese G3 rotavirus strains may be involved in the emergence of G3 rotavirus in China during 2001-2003.
VP7 substitutions may contribute to G3 rotavirus emergence; hypothesis-generating for antigenic surveillance and vaccine strain selection.
The distribution of rotavirus G-types in the world appears to be changing, especially with the emergence of G3 and G9 in many countries. Sequence analysis of the VP7 gene was performed on the 27 human G3 rotavirus strains isolated in China, Russia, Thailand, and Vietnam during 2001-2004. All the strains studied were clustered into the same branch of the phylogenetic tree. The comparison of the G3 deduced amino acid sequences between the studied Chinese strains and the strains circulating in China during 1986-1992 showed a wide range of amino acid substitutions (up to 13 amino acids in the VP7 antigenic regions). The two considerable changes both from aspartic acid to asparagine were located at positions 96 in antigenic region A and 213 in antigenic region C. Those amino acid substitutions of the Chinese G3 strains might involve in the emergence of G3 rotavirus in China during 2001-2003.
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Trinh et al. (2007) studied this question.
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