Key result
Sequence analysis of 52 human rotavirus G2 and G4 strains from Asia revealed specific phylogenetic clustering and amino acid substitutions, including an asparagine insertion in Japanese G4 strains.
Observational (n=52)
Yes
Sequence analysis identified specific amino acid substitutions and insertions in emerging G2 and G4 rotavirus strains in Asia during 2001-2003.
Sequence and phylogenetic analyses of the rotavirus VP7 gene were performed on 52 human G2 and G4 strains isolated in Japan, China, Thailand, and Vietnam during 2001-2003. All genotype G2 strains included in the study clustered into lineage II of the phylogenetic tree, together with the majority of global G2 strains detected since 1995. The amino acid substitution at position 96 from aspartic acid to asparagine was noted among the emerging or re-emerging G2 rotavirus strains in Japan, Thailand, and Vietnam during 2002-2003. Genotype G4 strains detected in Vietnam grouped into lineage Ia of the phylogenetic tree, whereas Japanese G4 strains clustered in lineage Ic which included emerging G4 strains from Argentina, Italy, Paraguay, and Uruguay. It is noteworthy that an insertion of asparagine was found at position 76 in all the Japanese strains and that its presence might be involved in the emergence of G4 rotavirus in Japan during 2002-2003.
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Trinh et al. (2010) conducted an observational in Human rotavirus G2 and G4 (n=52). Sequence and phylogenetic analyses of the rotavirus VP7 gene was evaluated on Phylogenetic clustering and amino acid substitutions. Sequence analysis of 52 human rotavirus G2 and G4 strains from Asia revealed specific phylogenetic clustering and amino acid substitutions, including an asparagine insertion in Japanese G4 strains.
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