What question did this study set out to answer?

To assess the clinical efficacy and tolerability of oral Matricaria recutita (chamomile) extract compared to placebo in outpatients with mild to moderate generalized anxiety disorder.

July 3, 2009Journal of Clinical Psychopharmacology

A Randomized, Double-Blind, Placebo-Controlled Trial of Oral Matricaria recutita (Chamomile) Extract Therapy for Generalized Anxiety Disorder

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Authors

JAJay D. AmsterdamCalifornia University of Pennsylvania YLYimei LiZhejiang A & F University ISIrene SoellerUniversity of Pennsylvania

Discussion

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Implication

Randomized double-blind trial demonstrates reduced anxiety symptoms with chamomile extract in generalized anxiety disorder, suggesting modest anxiolytic activity.

Key Points

To assess the clinical efficacy and tolerability of oral Matricaria recutita (chamomile) extract compared to placebo in outpatients with mild to moderate generalized anxiety disorder.
Enrolled 61 outpatients with mild to moderate generalized anxiety disorder, randomizing 57 participants to double-blind chamomile extract (n = 28) or placebo (n = 29) for 8 weeks.
Evaluated primary efficacy using change over time in total Hamilton Anxiety Rating (HAM-A) scores, alongside secondary measures including Beck Anxiety Inventory and Clinical Global Impression Severity scores.
Chamomile extract therapy achieved a significantly greater reduction in mean total HAM-A scores compared with placebo (P = 0.047).
One patient in each group discontinued treatment due to adverse events, and overall adverse event distribution did not differ significantly between arms (P = 0.417).

Cite This Study

Amsterdam et al. (2009) studied this question.

synapsesocial.com/papers/6a6fb38b8031ec7bb1dbe5fa https://doi.org/10.1097/jcp.0b013e3181ac935c

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Implication

Randomized double-blind trial demonstrates reduced anxiety symptoms with chamomile extract in generalized anxiety disorder, suggesting modest anxiolytic activity.

A Randomized, Double-Blind, Placebo-Controlled Trial of Oral Matricaria recutita (Chamomile) Extract Therapy for Generalized Anxiety Disorder

Discussion

Member takes

Implication

Key Points

Cite This Study

A Randomized, Double-Blind, Placebo-Controlled Trial of Oral Matricaria recutita (Chamomile) Extract Therapy for Generalized Anxiety Disorder

Discussion

Member takes

Implication

Key Points

Cite This Study

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