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October 1, 1981Infection and ImmunityOpen Access

Use of monoclonal antibody directed against herpes simplex virus glycoproteins to protect mice against acute virus-induced neurological disease

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Why the study?

Do monoclonal antibodies directed against HSV glycoproteins protect mice against acute virus-induced neurological disease and death?

Population

Mice inoculated with herpes simplex virus type 1 or type 2 via footpad

Comparison

Monoclonal antibodies HCl or HD1 administered… vs Single intraperitoneal injection of normal serum

Design

Preclinical

Follow-up

7 to 10 days

Authors

RDRichard D. DixEmory UniversityLPLenore PereiraUniversity of California, San FranciscoJBJ. Richard BaringerDartmouth College

Discussion

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Implication

Supports mAb protection in murine HSV models; leaves open human translation and trials.

Structured PICO

Do monoclonal antibodies directed against HSV glycoproteins protect mice against acute virus-induced neurological disease and death?

P
Population
Mice inoculated with herpes simplex virus type 1 (HSV-1, strains HTZ, MP, mP) or type 2 (HSV-2, strain G) via footpad
I
Intervention
Monoclonal antibodies HCl (anti-gC) or HD1 (anti-gD) administered via single intraperitoneal injection at 2 hours before or up to 24 hours after virus inoculation
C
Comparator
Single intraperitoneal injection of normal serum
O
Outcome
Neurological illness and deathhard clinical

Monoclonal antibodies against HSV glycoproteins gC and gD can passively immunize mice against acute virus-induced neurological disease and death.

Cite This Study

Dix et al. (1981) studied this question.

synapsesocial.com/papers/6a6fb41f35aa2c282ce10aa7https://doi.org/10.1128/iai.34.1.192-199.1981
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Type-common and type-specific monoclonal antibody to herpes simplex virus type 11980 · 239 citations
  2. 2Passive immunization in experimental Herpesvirus hominis infection of newborn mice1975 · 47 citations
  3. 3Host defenses in herpes simplex infections of the nervous system: effect of antibody on disease and viral spread1979 · 93 citations
  4. 4Membrane proteins specified by herpes simplex viruses. I. Identification of four glycoprotein precursors and their products in type 1-infected cells1976 · 296 citations
  5. 5Herpes-Simplex-Virus Encephalitis1965 · 133 citations