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January 28, 2006Journal of Biological ChemistryOpen Access

WT p53, but Not Tumor-derived Mutants, Bind to Bcl2 via the DNA Binding Domain and Induce Mitochondrial Permeabilization

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Authors

YTYork TomitaUnited States Food and Drug AdministrationNMN D MarchenkoStony Brook UniversitySESusan ErsterStony Brook University

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Tomita et al. (2006) studied this question.

synapsesocial.com/papers/6a6fb45ca528af2d65c31fa6https://doi.org/10.1074/jbc.m507611200
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Overexpression of the Bcl-2 Protein Increases the Half-life of p21Bax1995 · 105 citations
  2. 2Hypoxia death stimulus induces translocation of p53 protein to mitochondria2001 · 172 citations
  3. 3NMR Spectroscopy Reveals the Solution Dimerization Interface of p53 Core Domains Bound to Their Consensus DNA2001 · 87 citations
  4. 4In vitro folding and characterization of the p53 DNA binding domain2004 · 5 citations
  5. 5Direct Activation of Bax by p53 Mediates Mitochondrial Membrane Permeabilization and Apoptosis2004 · 2,051 citations