Maternal anti-RSV IgG antibodies decline rapidly in the first 6 months of life, with concentrations <20 RU/ml potentially indicating susceptibility to clinical RSV disease.
Maternal anti-RSV IgG decline may flag early infant susceptibility; hypothesis-generating for antibody thresholds before guiding prophylaxis.
The concentrations of maternal anti-RSV IgG antibodies were followed in 49 healthy newborns over the first six months of life. At birth, 41 mothers (83%) tested positive for anti-RSV IgG and all of their babies carried maternal anti-RSV IgG. Anti-RSV IgG positivity dropped to 73% at 1 month, 6% at 3 months, and 2% at 6 months. Between 3 and 6 months, 8% did acquire RSV infection, half of them as acute bronchiolitis and half as non-specific respiratory infection. All of the patients who acquired clinical RSV disease had an antibody concentration of <20 RU/ml which may be the cut off value for protection.
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Mustafa Hacımustafaoğlu (2004) studied this question.
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