Answers are grounded in this paper and cite their sources.
N-Benzyl p-anisamide 6, on lithiation with ButLi in the presence of HMPA, undergoes a stereoselective anionic cyclisation with loss of aromaticity to give a bicyclic enone which may be converted in nine steps to (±)-kainic acid.
No takes yet. Share an insight, caveat, or question.
Clayden et al. (2000) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: