Sex hormones drive changes in lipoprotein metabolism

Brief Summary: The authors explored the relationship between sex hormones and lipids in pre-pubertal children, young post-pubertal cisgender men and women, and transgender adolescents on gender affirming hormone (GAH) treatments using serum metabolomics to assess 149 lipids. High-density lipoproteins (HDL, typically atheroprotective) were higher and very-low- and low-density lipoproteins (typically atherogenic) were lower in post-pubertal cisgender women compared with cisgender men. There were no differences seen pre-puberty.