Case-control study reveals common genetic variants alter core immune genes through trans-regulatory networks in type 1 diabetes, highlighting an omnigenic disease architecture.
Brief summary: Using data on 4964 type 1 diabetes (T1D) cases and 7497 controls, this study assessed whether the effect of common genetic variants (SNPs) on risk of T1D is mediated through trans-effects on the expression of core genes. Nine putative core genes were identified, all implicated in immune system regulation. In addition, four T1D-associated genomic regions were identified as master regulators that have trans-effects on gene expression.
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Iakovliev et al. (2023) studied this question.
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