Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 15, 2026Diabetic Medicine

Trans‐ancestry meta‐analysis of genome‐wide association study identifies eight novel genetic loci in type 1 diabetes: A multi‐population study

View Full Paper
Ask AI
Bookmark
Share

Authors

XGXuying GuoHarbin Medical UniversityJHJingyang HuHarbin Medical UniversityHTHongsheng TianHarbin Medical University

Discussion

Loading...

Member takes

Implication

Trans-ancestry meta-analysis uncovers eight novel genetic risk loci for type 1 diabetes across European and Asian populations, highlighting the value of multi-ethnic genetic discovery.

Key Points

  • Identify novel genetic loci and pinpoint putative causal variants associated with type 1 diabetes by analyzing diverse ancestral populations.
  • Conducted a trans-ancestry genome-wide meta-analysis pooling 680,539 European individuals (12,525 cases, 668,014 controls) and 133,251 Asian individuals (1,219 cases, 132,032 controls).
  • Applied statistical fine-mapping and summary-data-based Mendelian randomization (SMR) to prioritize causal variants and evaluate gene-expression associations.
  • Identified 27 type 1 diabetes-associated loci, including 8 novel loci located near CDKAL1, NRSN1, FAM65B, LRRC16A, TULP1, SLC17A3, LRIG2, and C6orf1.
  • Pinpointed 7 putative causal variants (posterior probability > 0.95), including novel lead variants rs9366622 (PP = 0.976) near LRRC16A and rs1165190 (PP = 0.996) near SLC17A3.
  • Identified gene U91328.19 at the SLC17A3-rs1165190 locus as having an expression level causally associated with type 1 diabetes through SMR.

Cite This Study

Guo et al. (2026) studied this question.

synapsesocial.com/papers/6a8019ce75c2e31742c85f15https://doi.org/10.1111/dme.70434
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Role of HLA Class II Two‐Locus Haplotypes and Genotypes in Chinese With Type 1 Diabetes2025 · 2 citations
  2. 2Investigating Pleiotropy Between Depression and Autoimmune Diseases Using the UK Biobank2021 · 74 citations
  3. 3Systematic identification of trans eQTLs as putative drivers of known disease associations2013 · 1,802 citations
  4. 4Corrigendum to: Prevalence and incidence of type 1 diabetes in the world: a systematic review and meta-analysis Mobasseri M, Shirmohammadi M, Amiri T, Vahed N, Hosseini Fard H, Ghojazadeh M. Health Promot Perspect. 2020 Mar 30;10(2):98-115. doi: 10.34172/hpp.2020.182024 · 8 citations