Population
Murine 3T3-L1 preadipocytes, HEK293 cells, and J5 subclone of murine 3LL Lewis lung carcinoma cell line
Comparison
TNFalpha treatment, GM3 enrichment, and… vs Untreated control cells, mock-transfected cells…
Design
Preclinical
Authors
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Highlights potential GM3-mediated insulin resistance mechanism in adipocytes; leaves open therapeutic relevance pending human validation.
In adipocytes, insulin resistance induced by TNF-alpha causes accumulation of GM3, which dissociates the insulin receptor from caveolin-1 and impairs proper compartmentalization of insulin signaling.
Kabayama et al. (2007) studied this question.
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