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The neuropsychiatric clinical manifestations of tuberous sclerosis complex (TSC) include social and behavioral impairment, which are similar to the core symptoms of autism spectrum disorder (ASD). The present study examined the clinical effects of the mTOR inhibitor everolimus for 24 weeks on social and behavioral symptoms, and its relation of serum levels of the copper-and iron-binding antioxidants, such as ceruloplasmin (Cp) and transferrin (Tf), and superoxide dismutase (SOD) in a pre-pubercent boy and a girl child with TSC.
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Yui et al. (2018) studied this question.
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