Key result
Serum amyloid A isotypes colocalize with apolipoprotein B within atherosclerotic lesions.
Observational
Answers are grounded in this paper and cite their sources.
The polymorphic protein, serum amyloid A (SAA), consists of acute phase isotypes and a constitutive isotype. Both are associated mostly with high density lipoproteins (HDL) in the circulation. In the present study, both SAA isotypes were detected by immunohistochemistry and immunoblotting using monoclonal antibodies in atherosclerotic lesions. As the distribution of SAA was identical with that of apolipoprotein B and SAA is known to be associated also with low density lipoproteins (LDL), SAA may also be delivered to the artery wall by LDL.
No takes yet. Share an insight, caveat, or question.
Yamada et al. (1996) conducted an observational in Atherosclerosis. Serum amyloid A (SAA) was evaluated on Presence and distribution of SAA isotypes in atherosclerotic lesions. Both acute phase and constitutive serum amyloid A isotypes were detected in atherosclerotic lesions with a distribution identical to apolipoprotein B.
Synapse has enriched 10 related papers. Consider them for comparative context: