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November 20, 2024BMC Cardiovascular DisordersOpen Access

Sex hormones and reproductive factors with cardiac arrhythmia and ECG indices: a mendelian randomization study

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Why the study?

Sex determines the incidence and etiology of arrhythmia and basic studies implicate sex hormones, but the relationship between sex hormones and arrhythmia remains unclear.

Do genetically predicted sex hormone levels affect the risk of cardiac arrhythmias and alter ECG indices?

Population

GWAS data from the UK biobank consortium, FinnGen consortium, and summarized large GWAS data

Comparison

Genetically predicted sex hormone levels vs arrhythmia and ECG indices

Design

Mendelian randomization study

Authors

XWXishu WangZWZhaoyang WeiZZZheng Zuo

Discussion

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Overview

MR suggests estradiol may reduce AF risk in men; leaves open prospective validation before clinical translation.

Structured PICO

Do genetically predicted sex hormone levels affect the risk of cardiac arrhythmias and alter ECG indices?

P
Population
Large genome-wide association studies (GWAS) data on sex hormones from the UK biobank consortium (exposure) and data on arrhythmias and ECG indices from the FinnGen consortium and summarized large GWAS data.
I
Intervention
Genetically predicted levels of sex hormones (estradiol, total testosterone, bioavailable testosterone, sex hormone-binding globulin) and reproductive factors (age at menarche, age at menopause).
O
Outcome
Risk of atrial fibrillation (AF), atrioventricular block, sick sinus syndrome, paroxysmal tachycardia, and ECG indices.hard clinical

Genetically predicted higher estradiol levels are associated with a lower risk of atrial fibrillation in men, suggesting a potential sex-specific cardioprotective role of estradiol.

Limitations

  • Study population mainly European, limiting generalizability
  • Outcome data could not be stratified by sex due to lack of existing data
  • Inability to conduct nonlinear MR to analyze effects of changes in sex hormone concentrations
  • Exposure data for women predominantly represents postmenopausal individuals
  • Sample overlap and absence of sufficient relevant data constrained thorough analysis of specific arrhythmic conditions

Cite This Study

Wang et al. (2024) studied this question.

synapsesocial.com/papers/6a6fbb3b8031ec7bb1dbea62https://doi.org/10.1186/s12872-024-04335-7
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