Why the study?
Does 5alpha-dihydrotestosterone (DHT) treatment reduce dofetilide-induced prolongation of repolarization and early afterdepolarizations in normal female rabbits?
Population
Isolated preparations of ventricular endocardium from normal female rabbits
Comparison
5alpha-dihydrotestosterone treatment for 4… vs Age-matched normal control female rabbits…
Design
Preclinical
Follow-up
4 weeks
Authors
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DHT may reduce dofetilide-induced EADs in female rabbits; hypothesis-generating and should not change clinical practice.
Does 5alpha-dihydrotestosterone (DHT) treatment reduce dofetilide-induced prolongation of repolarization and early afterdepolarizations in normal female rabbits?
DHT treatment in female rabbits diminishes dofetilide-induced action potential prolongation and early afterdepolarizations, suggesting a protective role of androgens against drug-induced arrhythmias.
Pham et al. (2002) studied this question.
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