Why the study?
Does sodium desoxycholate alter the cellular potential and conduction properties of the sinoatrial node in rabbit hearts?
Does sodium desoxycholate alter the cellular potential and conduction properties of the sinoatrial node in rabbit hearts?
Sodium desoxycholate depresses the action potential and conduction velocity of rabbit sinoatrial nodal cells, an effect that is antagonized by norepinephrine.
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Should not change clinical practice; leaves open bile acid effects on human SA node function.
Sodium desoxycholate in a dose of 2.5×10-4 gm/ml decreased the slope of phase 4 of the action potential of the sinoatrial nodal cells of the rabbit heart and also decreased the amplitude, duration and rate of rise of the action potential.2. Its effect on the action potential of the sinoatrial nodal cells is not affected by atropine, but antagonized by norepinephrine.3. It decreased the conduction velocity of the impulses from S-A node to atrial muscle fibers or to the His' bundle.4. The sinoatrial cells are more sensitively depressed by sodium desoxycholate than the atrial muscle fibers.
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Tur‐Fu Huang (1969) studied this question.
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