Key result
Dexmedetomidine decreased the amplitude of action potential, velocity of diastolic depolarization, and rate of pacemaker firing in rabbit sinoatrial node pacemaker cells in a concentration-dependent manner.
Why the study?
Does dexmedetomidine alter the electrophysiological properties of pacemaker cells in sinoatrial nodes of rabbits?
Population
Healthy rabbits (sinoatrial node pacemaker cells)
Comparison
Dexmedetomidine with or without pretreatment… vs Baseline/control (normal pacemaker cells)
Design
Preclinical
Authors
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Warrants monitoring for bradycardia with dexmedetomidine; leaves open whether direct sinoatrial node effects translate to humans.
Does dexmedetomidine alter the electrophysiological properties of pacemaker cells in sinoatrial nodes of rabbits?
Dexmedetomidine exerts concentration-dependent inhibitory electrophysiological effects on rabbit sinoatrial node pacemaker cells, likely independent of alpha 2-adrenoreceptors.
Pan et al. (2015) studied this question. Dexmedetomidine vs. Baseline/control was evaluated on Amplitude of action potential, velocity of diastolic depolarization, and rate of pacemaker firing. Dexmedetomidine decreased the amplitude of action potential, velocity of diastolic depolarization, and rate of pacemaker firing in rabbit sinoatrial node pacemaker cells in a concentration-dependent manner.
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