Why the study?
Does increased plasma ADMA concentration predict the risk of future coronary events in initially healthy smoking and nonsmoking men?
Population
342 initially healthy men from the population-based MONICA/KORA study, as well as human endothelium-derived…
Comparison
High plasma asymmetric dimethylarginine… vs Low plasma ADMA concentration and nonsmoking…
Design
Case-control
Follow-up
median 6.2 (interquartile range 3.3-7.9) years
Authors
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ADMA was associated with coronary risk only in nonsmokers; leaves open its predictive value in smokers and requires prospective validation.
Does increased plasma ADMA concentration predict the risk of future coronary events in initially healthy smoking and nonsmoking men?
Increased plasma ADMA concentration predicts the risk of future coronary events in apparently healthy nonsmoking men, but not in smokers, potentially due to altered ADMA metabolism by tobacco smoke.
Maas et al. (2007) studied this question.
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