February 1, 2002Journal of the American Society of Nephrology
Asymmetric Dimethylarginine, C-Reactive Protein, and Carotid Intima-Media Thickness in End-Stage Renal Disease
Why the study?
Does plasma ADMA correlate with carotid intima-media thickness and its progression in patients undergoing hemodialysis?
Population
90 patients with end-stage renal disease undergoing hemodialysis
Design
Cohort
Follow-up
15 months
Authors
Discussion
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Member takes
Implication
ADMA-CRP interaction may flag hemodialysis patients for carotid lesion progression; leaves open whether targeting these markers improves outcomes.
Structured PICO
Does plasma ADMA correlate with carotid intima-media thickness and its progression in patients undergoing hemodialysis?
P
Population
90 patients with end-stage renal disease undergoing hemodialysis
O
Outcome
Relationship between plasma ADMA, C-reactive protein (CRP), and carotid intima-media thickness (IMT) and its progressionsurrogate
Plasma ADMA and CRP are interacting factors that independently predict the progression of carotid intimal lesions in hemodialysis patients, suggesting a link between ADMA, inflammation, and cardiovascular risk in chronic renal failure.
Cite This Study
Zoccali et al. (2002) studied this question.