This preclinical study demonstrates that the rate of repolarization plays a major role in determining the contractile response in rat atrial tissue.
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Repolarization rate may shape rat atrial contractility; hypothesis-generating for human atrial function, with no clinical implications yet.
Simultaneous recording of membrane potentials and contractility in isolated rat atria by means of intracellular micro-electrodes and a sensitive strain gage has been used to establish the normal characteristics of the tissue as well as effects of temperature, stimulus frequency and initial tension on muscle. Preliminary correlations between duration of the action potential and the degree of contraction indicate that the rate of repolarization is of major importance in determination of the contractile response.
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Hollander et al. (1955) studied this question.
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