January 1, 1959Circulation ResearchOpen Access

Effects of Enzyme Inhibitors on the Contractility and Membrane Potentials of the Rat Atrium

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Population

Rat atrium / rat atrial cells

Design

Preclinical

Authors

JWJ. WebbThe University of Sydney PHPHILIP B. HOLLANDERUniversity of Southern California

Discussion

Member takes

Implication

May confound atrial contractility assays; leaves open translation to human electrophysiology and function.

Structured PICO

Population

Rat atrium / rat atrial cells

Intervention

Enzyme inhibitors

Outcome

Contractility and membrane potentials (rate of ion movement, resting potential, action potential amplitude)surrogate

Enzyme inhibitors reduce rat atrial contractility through both membrane effects (shortened action potential duration) and direct effects on contractile processes.

Cite This Study

Webb et al. (1959) studied this question.

synapsesocial.com/papers/6a6fbc7987f9210571274acc https://doi.org/10.1161/01.res.7.1.131

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Effects of Enzyme Inhibitors on the Contractility and Membrane Potentials of the Rat Atrium

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effects of Enzyme Inhibitors on the Contractility and Membrane Potentials of the Rat Atrium

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider