April 1, 1998Journal of Biological ChemistryOpen Access

Characterization of a Ca2+ Release-activated Nonselective Cation Current Regulating Membrane Potential and Ca2+ Oscillations in Transgenically Derived β-Cells

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Population

Transgenically derived beta-cells (betaTC3-neo) and mouse beta-cells

Design

Preclinical

Authors

MRMichael W. RoeSUNY Upstate Medical University JWJennings F. WorleyVertex Pharmaceuticals (United States)FQFeng QianFudan University

Discussion

Member takes

Implication

May implicate TRP channels in beta-cell function; leaves open human translation and therapeutic relevance.

Structured PICO

Population

Transgenically derived beta-cells (betaTC3-neo) and mouse beta-cells

Intervention

Pharmacological modulation (tetraethylammonium, tolbutamide, thapsigargin, maitotoxin, SKF 96365) and external Na+ removal

Outcome

Membrane potential and intracellular Ca2+ ([Ca2+]i) oscillationssurrogate

Identifies a Ca2+ store depletion-activated nonselective cation current, likely encoded by trp genes, as the mechanism underlying glucose-stimulated oscillations in pancreatic beta-cells.

Cite This Study

Roe et al. (1998) studied this question.

synapsesocial.com/papers/6a6fbc805671bbf00bc29a4d https://doi.org/10.1074/jbc.273.17.10402

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Characterization of a Ca2+ Release-activated Nonselective Cation Current Regulating Membrane Potential and Ca2+ Oscillations in Transgenically Derived β-Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Characterization of a Ca2+ Release-activated Nonselective Cation Current Regulating Membrane Potential and Ca2+ Oscillations in Transgenically Derived β-Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider