Population
Purkinje fibers of sheep and fibers of the rabbit sinus
Design
Preclinical
Authors
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Hypothesis-generating for sodium-driven pacemaker activity in isolated cells; leaves open translation to mammalian sinoatrial node function.
This foundational preclinical study postulates that spontaneous cardiac pacemaker activity is driven by a high resting sodium current combined with a diastolic decrease in potassium conductance.
Trautwein et al. (1961) studied this question.
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