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January 1, 2010International Journal of Biological SciencesOpen Access

Smaller cardiac cell size and reduced extra-cellular collagen might be beneficial for hearts of Ames dwarf mice

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Why the study?

Does the Ames dwarf phenotype alter cardiac morphology (cell size, nuclear size, collagen content) compared to wild-type mice?

Population

Young adult (5-7 months) and old (24-28 months) Ames dwarf mice and wild-type littermates

Comparison

Ames dwarf genetic phenotype vs Wild-type littermates

Design

Preclinical

Authors

SHScott A. HelmsUniversity of Arkansas for Medical SciencesGAGohar AzharUniversity of Arkansas Medical CenterCZChunlai ZuoUniversity of California, Los Angeles

Discussion

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Implication

Hypothesis-generating for reduced cardiac remodeling in longevity models; leaves open human translation.

Structured PICO

Does the Ames dwarf phenotype alter cardiac morphology (cell size, nuclear size, collagen content) compared to wild-type mice?

P
Population
Young adult (5-7 months) and old (24-28 months) Ames dwarf mice and wild-type littermates
I
Intervention
Ames dwarf genetic phenotype
C
Comparator
Wild-type littermates
O
Outcome
Cardiac morphologic differences including cardiomyocyte cell size, nuclear size, and collagen contentsurrogate

Ames dwarf mice exhibit reduced cardiomyocyte size and lower early-adulthood cardiac collagen content, which may contribute to their observed longevity.

Cite This Study

Helms et al. (2010) studied this question.

synapsesocial.com/papers/6a6fbca6660549caf2c447b9https://doi.org/10.7150/ijbs.6.475
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